Glyburide crosses the placenta in vivo in pregnant rats
نویسندگان
چکیده
منابع مشابه
Effect of endotoxin on the expression of placental drug transporters and glyburide disposition in pregnant rats.
On average, 80% of pregnant women consume over-the-counter and/or prescription medications. The placenta is a crucial organ that can restrict fetal drug exposure. ATP-binding cassette (ABC) drug transporters play an important role in the placenta because they limit the transplacental transfer of xenobiotics. However, the impact of infection or inflammation on placental drug transporters is not ...
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15 صفحه اولShort Communication Increased Glyburide Clearance in the Pregnant Mouse Model
Glyburide (GLB) is an oral sulfonylurea, commonly used for the treatment of gestational diabetes mellitus. It has been reported that the clearance of GLB in pregnant women is significantly higher than that in nonpregnant women. The molecular mechanism by which pregnancy increases the clearance of GLB is not known, but it may be caused by increased CYP3A activity. Because liver tissue from pregn...
متن کاملIncreased glyburide clearance in the pregnant mouse model.
Glyburide (GLB) is an oral sulfonylurea, commonly used for the treatment of gestational diabetes mellitus. It has been reported that the clearance of GLB in pregnant women is significantly higher than that in nonpregnant women. The molecular mechanism by which pregnancy increases the clearance of GLB is not known, but it may be caused by increased CYP3A activity. Because liver tissue from pregn...
متن کاملthe effect of morphine consumption on plasma corticosteron concentration and placenta development in pregnant rats
abstract background: previous studies have shown that morphine consumption during pregnancy may delay embryo development or cause abnormal nervous system function. objective: the present study focused on the effect of maternal morphine consumption on development of placenta and blood corticosteron concentration in addictive pregnant mothers. materials and methods: 24 female rats, 170-200g weigh...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 1995
ISSN: 0012-186X,1432-0428
DOI: 10.1007/s001250050348